Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic초기 SARS-CoV-2 대유행을 이해하고 퇴치하기 위한 계통발생 및 계통역학적 접근Review Published on 2022-09-012022-09-11 Journal: Nature reviews. Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied approach combating coronavirus Determining effective epidemiological Genetic changes identify Infection International movement outbreak pandemic phylodynamic Phylogenetic phylogenies Prevalence provided public health SARS-CoV-2 SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus Spread the early SARS-CoV-2 Transmissibility Transmission variant virus [DOI] 10.1038/s41576-022-00483-8 PMC 바로가기 [Article Type] Review
BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults이종 프라임-부스트 백신 접종 후 BNT162b2 부스터는 젊은 성인에서 SARS-CoV-2 Omicron BA.1에 대한 강력한 중화 항체 및 T 세포 반응성을 유도합니다Article Published on 2022-07-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adults analysed Antibody titer Antibody titers B.1 B.1.1.529.1 BA.1 BNT162b2 booster Cell cellular immunity ChAdOx1 ChAdOx1 nCoV-19 Cohort Course COVID-19 defined Delta dominant Effect effective elicited Epitopes Heterologous heterologous prime-boost humoral humoral and cellular immunity Humoral immunity immune immune protection immune responses Immunity individual induce initial interval maturation memory T memory T cell memory T cells nCoV neutralization titer neutralization titers neutralized Neutralizing activity neutralizing antibody omicron performed reactivity residual responses against resulting SARS-CoV-2 SARS-COV-2 infection spike epitope spike epitopes subsequent symptomatic SARS-CoV-2 infection T cell T cells the early SARS-CoV-2 vaccination vaccination interval. Vaccinations variant variants variants of concern VOCs [DOI] 10.3389/fimmu.2022.882918 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China중국의 초기 COVID-19 전염병 동안 전통 공동체가 있는 중소 도시의 SARS-CoV-2 전파 특성Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] activities Analysis approach characterized China Chinese Cluster Community community transmission Complete COVID-19 case COVID-19 epidemic Culture effective Epidemics Epidemiology Evolution of SARS-CoV-2 Family size infections information Intrahost variant local outbreak MOST new SARS-CoV-2 occurred outbreak polymorphism profile profiles provided reference genome reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 transmission sequenced single-nucleotide single-nucleotide polymorphism Single-nucleotide polymorphism. strain the early SARS-CoV-2 the epidemic the SARS-CoV-2 Transmission transmission pattern variant Wuhan Wuhan, China [DOI] 10.1016/j.virs.2022.01.030 PMC 바로가기 [Article Type] Article
Consecutive deletions in a unique Uruguayan SARS-CoV-2 lineage evidence the genetic variability potential of accessory genes독특한 우루과이 SARS-COV-2 계보의 연속 결실Research Article Published on 2022-02-172022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accessory gene Accessory genes Amino acid amino acids B.1.1.33 capillary electrophoresis changes changes in clade collected Complete Deletion deletions downstream Evidence function fused fused protein genetic variability Genetic variation Genetic variations Genome genomic help Illumina include individual Lineage Next-generation sequencing nucleotide nucleotides occur Occurrence ORF ORF7a ORF7b peptide promote Protein Sanger sequencing SARS-CoV-2 SARS-CoV-2 lineage signal peptide the early SARS-CoV-2 the signal peptide transmembrane domain transmembrane protein unique virus [DOI] 10.1371/journal.pone.0263563 PMC 바로가기 [Article Type] Research Article
Codon usage divergence in Delta variants (B.1.617.2) of SARS-CoV-2SARS-CoV-2 델타 변이체(B.1.617.2)의 코돈 사용 차이Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adaptability Analysis B.1.617.2 Biodiversity calculated codon codon usage Codon usage divergence Codons coronavirus Delta delta variant Delta variants Delta variants (B.1.617.2) disease downloaded effective evaluate Gene evolution gene sequence Genome Human Mutation NCBI database new SARS-CoV-2 Non-synonymous Non-synonymous mutation Prognosis SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variants SARS-CoV-2. sequence sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spread standard deviations suggested synonymous the early SARS-CoV-2 the SARS-CoV-2 the SARS-CoV-2 genome third position Transmission variant variants [DOI] 10.1016/j.meegid.2021.105175 PMC 바로가기 [Article Type] Article
TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351)TMPRSS2 및 RNA 의존성 RNA 중합효소는 SARS-CoV-2 변이체(B.1.1.7 및 B.1.351)로 인한 COVID-19 치료를 위한 치료적 개입의 효과적인 표적입니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 신약개발, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral efficacy B.1.1.7 B.1.351 causative agent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Drug development drugs targeting effective Efficacy effort expected Factor Host in vitro inhibitor inhibitory effect Inhibitory effects Lineage Lineage B.1.1.7 measure monoclonal antibodies monoclonal antibody mutated pandemic problem public health RdRP RdRp inhibitor reported respiratory respond RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South Africa Spike protein target the early SARS-CoV-2 the SARS-CoV-2 therapeutic intervention therapeutic interventions Therapeutics TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Treatment treatment of COVID-19 United Kingdom Vaccine variant variants variants of concern Viral viral entry viral replication Viral RNA viral RNA-dependent RNA polymerase viral spike protein viruses while [DOI] 10.1128/Spectrum.00472-21 PMC 바로가기 [Article Type] Research Article
Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen박쥐에서 SARS-CoV-2의 진화에서 자연 선택은 일반 바이러스와 고도로 유능한 인간 병원체를 만들었습니다Research Article Published on 2021-03-122022-08-13 Journal: PLoS Biology [Category] Biology and Life Sciences, Fulltext, SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술, [키워드] accompanied acting acute respiratory syndrome coronavirus adaptive Analysis ancestor Anti-viral Antiviral base bat bat Sarbecovirus bats can not Cell Coinfection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CpG CpG composition detect early phase Evidence evidence of Evolution Evolution of SARS-CoV-2 horseshoe bats Host hosts Human human pathogen humans include involved Lineage lineages mechanism moderate natural natural selection nucleotide nucleotides pandemic positive Positive selection progenitor recombinant Recombination required respiratory reveal RmYN02 Sarbecoviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support the cells the early SARS-CoV-2 Transmission virus viruses while [DOI] 10.1371/journal.pbio.3001115 PMC 바로가기 [Article Type] Research Article
COVID-19 in cancer patients: clinical characteristics and outcome—an analysis of the LEOSS registry암 환자의 COVID-19: 임상 특성 및 결과 - LEOSS 레지스트리 분석Multicenter Study Published on 2020-11-072022-09-10 Journal: Annals of Hematology [Category] MERS, SARS, 치료기술, [키워드] active malignancy Adjusted analysis advanced age age age distribution Analysis analyzed anti-cancer treatments assumed Cancer cancer patient Cancer patients Clinical characteristics Cohort cohort study collected Comorbidities Comorbidity comparable conditions Course COVID-19 death rates determine distribution Endpoint enrolled European feature female higher risk ICU admission Infection LEOSS leukemia lymphoma majority Male sex malignancy mild symptoms Mortality mortality rate open outcome p value pandemic Patient patients primary endpoint Result Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe COVID-19 Sex significantly Solid solid tumors supplementary material survey the early SARS-CoV-2 Tumor tumors was performed [DOI] 10.1007/s00277-020-04328-4 PMC 바로가기 [Article Type] Multicenter Study
Susceptible supply limits the role of climate in the early SARS-CoV-2 pandemicReport Published on 2020-07-172022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Alter Analysis Baker change coronavirus coronavirus biology driving Effect effective Endemic Epidemic growth Hemisphere in some indicate infections Interaction Level limit measure Measures moderate modulate outbreak pandemic pathogen preliminary evidence proportion SARS-CoV-2 Science summer susceptibility susceptible temperature the early SARS-CoV-2 the SARS-CoV-2 trajectory Transmission Variation virus transmission [DOI] 10.1126/science.abc2535 PMC 바로가기 [Article Type] Report